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Functional characterization of the recombinant HIV-neutralizing monoclonal antibody 2F5 produced in maize seeds

✍ Scribed by Sabalza, M.; Madeira, L.; Dolleweerd, C.; Ma, J. K.; Capell, T.; Christou, P.


Book ID
118808316
Publisher
Springer
Year
2012
Tongue
English
Weight
591 KB
Volume
80
Category
Article
ISSN
0167-4412

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The human monoclonal antibody (humAb) 2F5 is a potent candidate for immunotherapy of HIV-1. The xenohybridoma derived humAb 2F5 is of IgG3 kappa isotype. Generally, IgG1 isotype has a longer half-life (␤clearance) in humans than IgG3. Therefore the isotype was switched to an IgG1 by ligation of the