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The melatonin metabolite N1-acetyl-5-methoxykynuramine is a potent singlet oxygen scavenger

✍ Scribed by Meike Schaefer; Rüdiger Hardeland


Book ID
111264607
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
175 KB
Volume
46
Category
Article
ISSN
0742-3098

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✍ Víctor Tapias; Germaine Escames; Luis C. López; Ana López; Encarnación Camacho; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 181 KB

## Abstract Melatonin prevents mitochondrial failure in models of sepsis through its ability to inhibit the expression and activity of both cytosolic (iNOS) and mitochondrial (i‐mtNOS) inducible nitric oxide synthases. Because Parkinson's disease (PD), like sepsis, is associated with iNOS induction