The mechanism of acetoacetate coupling in the biosynthesis of hygrine

✍ Scribed by Brian A. McGaw; Jack G. Woolley

• Book ID: 104246339
• Publisher: Elsevier Science
• Year: 1979
• Tongue: French
• Weight: 182 KB
• Volume: 20
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)95341-9

✦ Synopsis

Sodium[3-14C]-and [4-14C]-acetoacetate were wick fed to 3-month-old Nicandra physaZoides plants. The hygrine was isolated and by degradation it was shown that acetoacetate is a precursor. It was also shown that the C(2) carbon is the reactive site in its condensation with the N-methyl-A'-pyrrolinium cation. Carbons (2), (3) and (4) of the tropane ring (V) were shown by Kaczkowski et al 'y2 *_-* to be derived from acetate. In separate feeds with [l-14C]-acetate and [2-14C]-acetate to