The MDM2–p53 pathway: multiple roles in kidney development
✍ Scribed by El-Dahr, Samir S.; Hilliard, Sylvia; Aboudehen, Karam; Saifudeen, Zubaida
- Book ID
- 121548178
- Publisher
- Springer
- Year
- 2013
- Tongue
- English
- Weight
- 588 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-041X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The 5th subunit of COP9 signalosome (CSN5, also known as Jab1 or COPS5) is implicated in regulating p53 activity and is overexpressed in various tumors. However, the precise roles of CSN5 in p53 network and tumorigenesis are not well characterized. Here we show that CSN5 is a critical r
## Abstract The powerful tumor suppressor p53 takes charge of a regulatory network to guard over the living cells from harmful effect of different forms of stress and eradicate the tumor cells for normal physiological condition maintenance. However the antitumor function of p53 is often attenuated