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The Mcm2-7 Complex Has In Vitro Helicase Activity

โœ Scribed by Matthew L. Bochman; Anthony Schwacha

Book ID
116754565
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
803 KB
Volume
31
Category
Article
ISSN
1097-2765

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## Abstract **Background:** MCM and Cdc45 are required for the initiation and elongation stages of eukaryotic DNA replication. Recent studies show that a purified Mcm4/6/7 complex has DNA helicase activity. However, the biochemical function of the MCM complex and Cdc45 bound to chromatin has not be