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Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

✍ Scribed by Ivar Ilves; Tatjana Petojevic; James J. Pesavento; Michael R. Botchan

Book ID
116754815
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
802 KB
Volume
37
Category
Article
ISSN
1097-2765

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## Abstract **Background:** MCM and Cdc45 are required for the initiation and elongation stages of eukaryotic DNA replication. Recent studies show that a purified Mcm4/6/7 complex has DNA helicase activity. However, the biochemical function of the MCM complex and Cdc45 bound to chromatin has not be