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Interactions of human Cdc45 with the Mcm2–7 complex, the GINS complex, and DNA polymerases δ and ɛ during S phase

✍ Scribed by Christina Bauerschmidt; Sibyll Pollok; Elisabeth Kremmer; Heinz-Peter Nasheuer; Frank Grosse

Book ID
108731942
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
391 KB
Volume
0
Category
Article
ISSN
1356-9597

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✍ Taro Masuda; Satoru Mimura; Haruhiko Takisawa 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 574 KB

## Abstract **Background:** MCM and Cdc45 are required for the initiation and elongation stages of eukaryotic DNA replication. Recent studies show that a purified Mcm4/6/7 complex has DNA helicase activity. However, the biochemical function of the MCM complex and Cdc45 bound to chromatin has not be