✦ LIBER ✦

The mast cell and synovial inflammation

✍ Scribed by Stephen I. Wasserman

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 378 KB
Volume: 27
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780270801

No coin nor oath required. For personal study only.

✦ Synopsis

The reports in this issue of Arthritis and Rheumatism which identify the mast cell as a participant in inflammatory synovitis (1,2) add a further layer of complexity to the pathophysiology of joint disorders. In this regard, it is appropriate to review recent advances in the understanding of mast cells in an attempt to place their potential role in synovium in perspective. It is pertinent to consider the mast cell as a marker for inflammatory processes, as a potential effector cell both directly and indirectly in the pathophysiology of arthritis, and as a homeostatic regulator of ongoing inflammation.

MAST CELLS AS MARKERS OF INFLAMMATORY DISORDERS

In normal circumstances, mast cells are found predominantly at the host-environment interface: in skin, respiratory tract, and gastrointestinal tract, where they occur in the mucosa and especially in loose connective tissue, and most often around blood vessels and nerves. They are present at concentrations of 7,000-12,000/mm3 in skin (3), 20,000/mm3 in the gastrointestinal tract (4) and, based upon histamine content, a nearly identical number may be found in the lung.

Increased numbers of mast cells have been identified in tissue in a variety of inflammatory states.

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