✦ LIBER ✦

Participation of synovial mast cells in intermittent hydrarthrosis

✍ Scribed by Daniel G. Malone; Ronald L. Wilder

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 251 KB
Volume: 32
Category: Article
ISSN: 0004-3591
DOI: 10.1002/anr.1780320323

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✦ Synopsis

Although the patient had symptoms and physical and histologic features of WG, we suggest the illness was caused by methyldopa. Most important, the patient had no evidence of pulmonary or renal involvement, and the disorder resolved without the use of steroids or cytotoxic agents.

Allopurinol can also cause severe hepatic disease, occurring chiefly in patients with renal insufficiency (7). However, the time course of the disease and the normal renal function in this patient provide evidence against allopurinol as the causative agent. Synergy between allopurinol and methyldopa leading to this reaction is a possible, but not previously reported, mechanism of toxicity.

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