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The Mammalian Mre11-Rad50-Nbs1 Protein Complex: Integration of Functions in the Cellular DNA–Damage Response

✍ Scribed by John H.J. Petrini

Book ID
117852836
Publisher
American Society of Human Genetics
Year
1999
Tongue
English
Weight
133 KB
Volume
64
Category
Article
ISSN
0002-9297

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## Abstract Mre11, Rad50, and Nbs1form a tight complex which is homogeneously distributed throughout the nuclei of mammalian cells. However, after irradiation, the Mre11/Rad50/Nbs1 (M/R/N) complex rapidly migrates to sites of double strand breaks (DSBs), forming foci which remain until DSB repair i