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The magnitude of the CD8+ T cell response produced by recombinant virus vectors is a function of both the antigen and the vector

✍ Scribed by James Millar; Dilan Dissanayake; Teng Chih Yang; Natalie Grinshtein; Carole Evelegh; Yonghong Wan; Jonathan Bramson


Book ID
113527093
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
329 KB
Volume
250
Category
Article
ISSN
0008-8749

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✍ Marie J. Estcourt; Andrew J. McMichael; Tomáš Hanke 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 255 KB 👁 1 views

## Abstract T cell receptor‐transgenic F5 mice were used to assess primary CD8^+^ T cell responses to a modified virus Ankara (MVA)‐vectored vaccine in the absence of CD4^+^ T cell help. Naive, CD8‐enriched, CFSE‐labelled F5 cells were transferred into normal or CD4^+^ cell‐depleted mice and the mi