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The Immunogenicity of Adenovirus Vectors Limits the Multispecificity of CD8 T-cell Responses to Vector-encoded Transgenic Antigens

✍ Scribed by Schirmbeck, Reinhold; Reimann, Jörg; Kochanek, Stefan; Kreppel, Florian


Book ID
126988407
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
365 KB
Volume
16
Category
Article
ISSN
1525-0016

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## Abstract ## Background The ability to induce cytotoxic T lymphocyte (CTL) responses that are multispecific is considered to comprise an essential feature for an efficacious genetic vaccine against many pathogens including HIV and hepatitis C virus. ΔE1Ad vectors are promising vectored vaccines