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The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

✍ Scribed by Hidetoshi Hayashi; Shirin Abdollah; Yubin Qiu; Jiexing Cai; Yong-Yao Xu; Brian W Grinnell; Mark A Richardson; James N Topper; Michael A Gimbrone Jr.; Jeffrey L Wrana; Dean Falb


Book ID
117267291
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
262 KB
Volume
89
Category
Article
ISSN
0092-8674

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✍ Gudrun Valdimarsdottir; Marie-José Goumans; Fumiko Itoh; Susumu Itoh; Carl-Henri 📂 Article 📅 2006 🏛 BioMed Central 🌐 English ⚖ 664 KB

## Background In endothelial cells (EC), transforming growth factor-β (TGF-β) can bind to and transduce signals through ALK1 and ALK5. The TGF-β/ALK5 and TGF-β/ALK1 pathways have opposite effects on EC behaviour. Besides differential receptor binding, the duration of TGF-β signaling is an important