The M5 muscarinic receptor as possible target for treatment of drug abuse
โ Scribed by R. B. Raffa
- Book ID
- 108849265
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 211 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0269-4727
No coin nor oath required. For personal study only.
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Anticholinergic drugs are used to treat a number of neurologic disorders, inctuding parkinsonism, vestibular disturbances, and dystonia. Traditionally, these drugs have been thought to act in similar fashion, as competitive antagonists at a single class of muscarink receptors, and not to differ sign
## Abstract Neuronal nicotinic acetylcholine receptor (nAChR) agonists have been demonstrated to exhibit antinociceptive, antihyperalgesic, and antiallodynic effects across a range of preclinical models of pain. Yet, to date, no drugs have been successfully developed and approved for the treatment