The LRRK2 G2019S mutation status does not affect the outcome of subthalamic stimulation in patients with Parkinson's disease
β Scribed by Greenbaum, Lior; Israeli-Korn, Simon D.; Cohen, Oren S.; Elincx-Benizri, Sandra; Yahalom, Gilad; Kozlova, Evgenia; Strauss, Hanna; Molshatzki, Noa; Inzelberg, Rivka; Spiegelmann, Roberto; Israel, Zvi; Hassin-Baer, Sharon
- Book ID
- 121324112
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 204 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1353-8020
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## Abstract Mutations in the LeucineβRich Repeat Kinase 2 gene (__LRRK2__) are mainly responsible for idiopathic Parkinson's disease (PD) with either a dominant pattern of transmission or a sporadic occurrence due to the reduced penetrance. A majority of __LRRK2__ kindreds demonstrate an extremely
To evaluate the frequency of the LRRK2 G2019S mutation in Italy, we tested 1,072 probands with Parkinson's disease (PD; 822 sporadic and 250 familial): 20 patients (1.9%) carried the G2019S mutation, 11 patients (1.3%) were sporadic, and 9 (4.3%) had a positive family history. Considering only proba