The long-term clinical implications of clonal chromosomal abnormalities in newly diagnosed chronic phase chronic myeloid leukemia patients treated with imatinib mesylate
โ Scribed by Sung-Eun Lee; Soo Young Choi; Ju-Hee Bang; Soo-Hyun Kim; Eun-jung Jang; Ji-Young Byeun; Jin Eok Park; Hye-Rim Jeon; Yun Jeong Oh; Myungshin Kim; Dong-Wook Kim
- Book ID
- 119211557
- Publisher
- Elsevier
- Year
- 2012
- Tongue
- English
- Weight
- 436 KB
- Volume
- 205
- Category
- Article
- ISSN
- 2210-7762
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## Abstract ## BACKGROUND The International Randomized study of Interferonโalpha plus cytarabine (IFNโฮฑ plus araโC) versus STI571 (imatinib mesylate) [IRIS trial] in patients with newly diagnosed Philadelphia chromosome (Ph)โpositive, chronicโphase chronic myelogenous leukemia (CML) has not shown
## Abstract ## BACKGROUND: The European LeukemiaNet recommendations for chronic myeloid leukemia (CML) defined a group of patients with suboptimal response to imatinib. The significance of this response was not well defined. ## METHODS: The significance of having had a suboptimal response during