Long-term safety and efficacy of imatinib mesylate (Gleevec®) in elderly patients with chronic phase chronic myelogenous leukemia: Results of the AFR04 study
✍ Scribed by Philippe Rousselot; Pascale Cony-Makhoul; Franck Nicolini; François Xavier Mahon; Christian Berthou; Delphine Réa; Josy Reiffers; Anne Bornand; Olivier Saint-Jean; Joelle Guilhot; François Guilhot; on behalf of the French Intergroup For Chronic Myelogenous Leukemia (Fi-LMC)
- Book ID
- 115549282
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 177 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0361-8609
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## Abstract ## BACKGROUND Imatinib mesylate induces high rates of hematologic and cytogenetic response in patients with chronic myelogenous leukemia (CML). During therapy with imatinib, up to 45% of patients with CML reportedly experience myelosuppression ≥ Grade 3, requiring interruption of thera
## Abstract ## BACKGROUND. The tolerability and efficacy of the combination of tipifarnib, an orally bioavailable nonpeptidomimetic farnesyl transferase inhibitor, and imatinib was investigated in patients with chronic myelogenous leukemia in chronic phase who had failed imatinib. ## METHODS. Tw