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The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)

✍ Scribed by Valge-Archer, V; Forster, A; Rabbitts, T H


Book ID
110061809
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
267 KB
Volume
17
Category
Article
ISSN
0950-9232

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Nearly 30 percent of patients with T-cell acute lymphoblastic leukemia (T-ALL) exhibit a tumor-specific rearrangement of the TALI gene (also called TCLS or SCL). These rearrangements are generated by either local D N A deletion or a (I ; 14)(p34;q I I ) chromosome translocation, and they typically r