The translocation (1;14)(p34;q11) in human t-cell leukemia: Chromosome breakage 25 kilobase pairs downstream of the tal1 protooncogene
✍ Scribed by Ying Xia; Lamorna Brown; Julia Tsou Tsan; Cary Ying Chuan-Yang; Richard Baer; Michael J. Siciliano; William M. Crist; Andrew J. Carroll
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 626 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
Nearly 30 percent of patients with T-cell acute lymphoblastic leukemia (T-ALL) exhibit a tumor-specific rearrangement of the TALI gene (also called TCLS or SCL). These rearrangements are generated by either local D N A deletion or a (I ; 14)(p34;q I I ) chromosome translocation, and they typically result in structural alterations of the TALI transcription unit. In this report we present a molecular characterization of the t( I; 14)(p34;q I I) from a T-ALL patient. As a consequence of the translocation, TALI is transposed from its normal position on chromosome I into the T-cell receptor 0(/6 chain locus on chromosome 14. Unlike previous cases, the chromosome I breakpoint in this patient did not disrupt the continuity of the TALI transcription unit, but instead occurred approximately 25 kilobase pairs (kb) downstream of TALI. This observation suggests that malignant alteration of TALI can be mediated by long-range cis-activating mechanisms that are triggered by D N A rearrangement at a distant site.