The lipid peroxidation product 4-hydroxynonenal is a potent inducer of the SOS response
β Scribed by Benamira, Mounir; Marnett, Lawrence J.
- Book ID
- 122475121
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 737 KB
- Volume
- 293
- Category
- Article
- ISSN
- 0921-8777
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i y ; 11 Life Sciences Division, Ceri 4-Hydroxynonenal (HNE) is produced during peroxidation of polyunsaturated fatty acids. It exerts a chemokinetic effect on human polymorphonuclear leukocytes (PMN). Investigations of this mechanism were performed. The results indicate that [3H]-HNE binding to PMN
Hydroxynonenal is a product formed in tissue and tissue fractions from polyunsaturated membrane lipids through a free radical-induced lipid peroxidation process. The biological properties of this aldehyde have been studied in many respects. This article describes for the first time a sensitive and r