✦ LIBER ✦

The lipid A immunity system. I. Induction of heterophile antibodies by enterobacterial lipopolysaccharides and their lipid A component

✍ Scribed by W.-R. Rank; R. Dipauli; U. Flügge-Rank

Publisher: John Wiley and Sons
Year: 1972
Tongue: English
Weight: 587 KB
Volume: 2
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830020610

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✦ Synopsis

The lipid A immunity system 1. Induction of heterophile antibodies by enterobacterial lipopolysaccharides and their lipid A component Mice were immunized either with lipopolysaccharides (LPS) or with the respective lipid A components. After four days an increase in the number of direct plaque-forming cells with complement-dependent antibody against sheep red cells was seen. Cross-reactions were observed with red cells of cattle, goats, horses and rabbits. All LPS investigated, of Shigella, Escherichia coli, and S and R form Salmonella, as well as the lipid A component evoked this immune response. We therefore conclude that all enterobacterial LPS induce an antibody which cross-reacts with SRC and that the lipid A component is responsible for this reaction. Evidence is presented that these effects, such as toxicity, fever, pyrogen tolerance, leucopenia/leucocytosis, nonspecific immunity, and tumor inhibition are mediated by lipid A-induced antibodies.

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