The levels of RAC3 expression are up regulated by TNF in the inflammatory response

✍ Scribed by Alvarado, Cecilia Viviana; Rubio, María Fernanda; Fernández Larrosa, Pablo Nicolas; Panelo, Laura Carolina; Azurmendi, Pablo Javier; Ruiz Grecco, Marina; Martínez-Nöel, Giselle Astrid; Costas, Mónica Alejandra

• Book ID: 123436318
• Publisher: Wiley (John Wiley & Sons)
• Year: 2014
• Tongue: English
• Weight: 544 KB
• Volume: 4
• Category: Article
• ISSN: 2211-5463
• DOI: 10.1016/j.fob.2014.04.009

✦ Synopsis

Highlights

•The inflammatory response increases the expression of RAC3 in vitro and in vivo.

•TNF induces the increase of RAC3 at transcriptional level through NF-κB activation.

•Glucocorticoids also induce the increase of RAC3 expression levels.

•RAC3 appears to be essential for NF-κB- and GR-mediated transcription.