The level of HER2/neu gene amplification as predictive factor in patients with metastatic breast cancer treated with a trastuzumab-based therapy
โ Scribed by G. Gullo; D. Bettio; V. Torri; G. Masci; P. Salvini; A. Santoro
- Book ID
- 119598390
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 59 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1359-6349
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## Abstract Herโ2/__neu__ overexpression in human breast cancer leads to an aggressive biological behavior and poor prognosis. Although the antiโHerโ2/__neu__ antibody trastuzumab (Herceptinยฎ) has become a valuable therapeutic option for patients with Herโ2/__neu__โoverexpressing breast cancer, man
## Abstract ## BACKGROUND: Only a portion of breast cancer patients currently selected for trastuzumab therapy respond. ## METHODS: Using a novel assay (HERmark) to quantify total human epidermal growth factor receptor 2 (HER2) expression, the authors examined outcomes in 102 trastuzumabโtreated