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The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy

✍ Scribed by Christ, Frauke; Debyser, Zeger

Book ID: 118504263
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 545 KB
Volume: 435
Category: Article
ISSN: 0042-6822
DOI: 10.1016/j.virol.2012.09.033

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## Abstract A crystal structure of the integrase binding domain (IBD) of the lens epithelium‐derived growth factor (LEDGF/p75) in complex with the dimer of the HIV‐1 integrase (IN) catalytic core domain (CCD) provides useful information that might help in the understanding of essential protein‐prot