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The Lathyrus excitotoxin β-N-oxalyl-l-α,β-diaminopropionic acid is a substrate of the l-cystine/l-glutamate exchanger system xc−

✍ Scribed by Brady A. Warren; Sarjubhai A. Patel; Peter B. Nunn; Richard J. Bridges


Book ID
113923357
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
479 KB
Volume
200
Category
Article
ISSN
0041-008X

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✍ Stephan Miller; Peter B. Nunn; Richard J. Bridges 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 1020 KB

p-N-Oxalyl-L-a$-diaminopropionic acid (P-L-ODAP) is thought to be the causative agent in lathyrism due to its neuroexcitatory and neurotoxic properties. We have recently reported that P-L-ODAF' is also gliotoxic at high concentrations (Bridges et al.: Brain Res 561:262, 1991). Evidence is now presen