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The laminin binding integrin α6β1 in prostate cancer perineural invasion

✍ Scribed by Isis C. Sroka; Todd A. Anderson; Kathy M. McDaniel; Raymond B. Nagle; Matthew B. Gretzer; Anne E. Cress

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
280 KB
Volume
224
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Metastasizing prostate tumor cells invade along nerves innervating the encapsulated human prostate gland in a process known as perineural invasion. The extacellular matrix laminin class of proteins line the neural route and tumor cells escaping from the gland express the laminin binding integrin α6β1 as a prominent cell surface receptor. Integrin α6β1 promotes aggressive disease and supports prostate tumor cell metastasis to bone. Laminins and their integrin receptors are necessary for the development and maintenance of the peripheral nervous system, indicating the potential role for integrin receptors in directing prostate tumor cell invasion on nerves during perineural invasion. J. Cell. Physiol. 224: 283–288, 2010. © 2010 Wiley‐Liss, Inc.

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