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The lack of effects of pretreatment with phenobarbital and chlorpromazine on the acute toxicity of benzene in rats

✍ Scribed by Robert T. Drew; James R. Fouts


Book ID
119001932
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
784 KB
Volume
27
Category
Article
ISSN
0041-008X

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πŸ“œ SIMILAR VOLUMES


Effect of phenobarbital pretreatment on
✍ I. Gut πŸ“‚ Article πŸ“… 1976 πŸ› Springer-Verlag 🌐 English βš– 704 KB

Phenobarbital pretreatment (50 mg/kg/day for 3 days orally) of male Wistar rats increased Vmax of benzene in vitro hepatic microsomal biotransformation about 6-fold without changing Km. However, benzene blood levels after oral, intraperitoneal, or subcutaneous benzene administration (3-3.5 mmoles/kg