The lack of effect of ziprasidone on platelet serotonin concentration in schizophrenic patients
โ Scribed by Marina Sagud; Matea Nikolac; Alma Mihaljevic-Peles; Gordana Nedic; Bjanka Vuksan Cusa; Maja Mustapic; Miro Jakovljevic; Dorotea Muck-Seler; Nela Pivac
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 69 KB
- Volume
- 219
- Category
- Article
- ISSN
- 0033-3158
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We have studied the acute and chronic effects of an ACE inhibitor (captopril) on platelet function and the renin-angiotensin system in patients with congestive heart failure. Plasma concentrations of angiotensin II fell significantly after a single dose of captopril (25 mg) and during long-term trea
The active uptake of serotonin (5-HT) by blood platelets of 20 schizophrenic patients and their families was studied. The uptake was studied over a wide range of 5-HT concentrations (0.1-20 ~tM), and K,, and Vmax of the uptake process were calculated. Of 20 patients, 18 exhibited a lower rate of upt