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A lack of effect of captopril on platelet aggregation in patients with congestive heart failure

✍ Scribed by I. F. Gow; A. D. Flapan; M. Morris; E. Davies; B. C. Williams; P. L. Padfield; T. R. D. Shaw; C. R. W. Edwards

Publisher
Springer
Year
1991
Tongue
English
Weight
319 KB
Volume
41
Category
Article
ISSN
0031-6970

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✦ Synopsis

We have studied the acute and chronic effects of an ACE inhibitor (captopril) on platelet function and the renin-angiotensin system in patients with congestive heart failure. Plasma concentrations of angiotensin II fell significantly after a single dose of captopril (25 mg) and during long-term treatment with captopril (2 weeks, 75 mg/day). Plasma renin activity increased significantly after both the single and repeated doses. Captopril did not affect ADP-induced platelet aggregation or concentrations. It seems unlikely that circulating angiotensin II affects ADP-induced platelet aggregation in patients with congestive heart failure.

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