The kinetics and mechanism of a highly efficient intramolecular nucleophilic reaction. The cyclization of ethyl N-[o-(N-hydroxycarbamoyl)benzoyl]-carbamate to N-hydroxyphthalimide

Kinetics and mechanism for the formation

Kinetics and mechanism for the formation of o-carboxy(N-methyl)-benzohydroxamic acid in the cleavage of ethyl N-[o-(N-methyl-N-hydroxycarbamoyl)-benzoyl]carbamate in N-methylhydroxylamine, acetate, and phosphate buffers

✍ M. Niyaz Khan 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB 👁 1 views

The rate of cleavage of ethyl N-[o -(N-methyl-N-hydroxycarbamoyl)benzoyl]carbamate (ENMBC) in the buffer solutions containing N-methylhydroxylamine, acetate + Nmethylhydroxylamine, and phosphate + N-methylhydroxylamine followed an irreversible consecutive reaction path: ENMBC k 1 obs → A k 2 obs → B