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The kinase activity of Cdk9 is required for phosphorylation of p300 and acetylation of GATA4 as well as cardiomyocyte hypertrophy

✍ Scribed by Yoichi Sunagawa; Tatsuya Morimoto; Tomohide Takaya; Teruhisa Kawamura; Hiromichi Wada; Akira Shimatsu; Masatoshi Fujita; Toru Kita; Koji Hasegawa


Book ID
116339054
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
48 KB
Volume
14
Category
Article
ISSN
1532-8414

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## Abstract P‐TEFb functions to induce the elongation step of RNA polymerase II transcription by phosphorylating the carboxyl‐terminal domain of the largest subunit of RNA polymerase II. Core P‐TEFb is comprised of Cdk9 and a cyclin regulatory subunit, with Cyclin T1 being the predominant Cdk9‐asso