Histone acetylation is essential for ANG
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Chun-Hsien Chu; Jeng-Fan Lo; Wei-Syun Hu; Ru-Band Lu; Mu-Hsin Chang; Fuu-Jen Tsa
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Article
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2011
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John Wiley and Sons
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English
⚖ 716 KB
## Abstract The IGF‐II/mannose 6‐phosphate receptor (IGF‐IIR/Man‐6‐P) up‐regulation correlates with heart disease progression and its signaling cascades directly trigger pathological cardiac hypertrophy, fibrosis, and cardiomyocytes apoptosis. IGF‐IIR gene expression/ suppression is able to prevent