✦ LIBER ✦

The Kennedy pathway—De novo synthesis of phosphatidylethanolamine and phosphatidylcholine

✍ Scribed by Federica Gibellini; Terry K. Smith

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 941 KB
Volume: 62
Category: Article
ISSN: 1521-6543
DOI: 10.1002/iub.337

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The glycerophospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE) account for greater than 50% of the total phospholipid species in eukaryotic membranes and thus play major roles in the structure and function of those membranes. In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn‐1,2‐diradylglycerol and either CDP‐choline or CDP‐ethanolamine, respectively. This is the last step in a biosynthetic pathway known as the Kennedy pathway, so named after Eugene Kennedy who elucidated it over 50years ago. This review will cover various aspects of the Kennedy pathway including: each of the biosynthetic steps, the functions androles of the phospholipid products PC and PE, and how the Kennedy pathway has the potential of being a chemotherapeutic target against cancer and various infectious diseases. © 2010 IUBMB IUBMB Life, 62(6): 414–428, 2010

📜 SIMILAR VOLUMES

The Kennedy pathway—De novo synthesis of

The Kennedy pathway—De novo synthesis of phosphatidylethanolamine and phosphatidylcholine

✍ Federica Gibellini; Terry K. Smith 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 109 KB 👁 1 views

## Abstract The Kennedy Pathway. See The Kennedy Pathway–De Novo Synthesis of Phosphatidylethanolamine and Phosphatidylcholine by Federica Gibellini and Terry K. Smith, pp. 414–428.

The de Novo pathway of purine nucleotide

The de Novo pathway of purine nucleotides

✍ Usha Anand; C. V. Anand 📂 Article 📅 2002 🏛 The American Society for Biochemistry and Molecula 🌐 English ⚖ 21 KB 👁 1 views

First De Novo Synthesis of the Bisindole

First De Novo Synthesis of the Bisindole Alkaloid Vinblastine

✍ Christoph Schneider 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 77 KB

First De Novo Synthesis of the Bisindole

First De Novo Synthesis of the Bisindole Alkaloid Vinblastine.

✍ Christoph Schneider 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 49 KB

On the de novo synthesis of polychlorina

On the de novo synthesis of polychlorinated dibenzo-p-dioxins and dibenzofurans

✍ J. J. Janssens; P. J. C. Schepens 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 333 KB

Glia-conditioned medium induces de novo

Glia-conditioned medium induces de novo synthesis of tyrosine hydroxylase and increases dopamine cell survival by differential signaling pathways

✍ S. de Bernardo; S. Canals; M. J. Casarejos; E. Rodriguez-Martin; M. A. Mena 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 711 KB

## Abstract The mesencephalic astroglia‐conditioned medium (GCM) greatly increases dopamine (DA) phenotype expression, and it also protects from spontaneous and toxin‐induced cell death in midbrain cultures. In this study, we have investigated the signaling pathways implicated in those effects. Gen