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The islet amyloid polypeptide gene and non-insulin-dependent diabetes mellitus in South Indians

✍ Scribed by M.I. McCarthy; G.A. Hitman; V. Mohan; A. Ramachandran; C. Snehalatha; M. Viswanathan


Book ID
119135244
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
306 KB
Volume
18
Category
Article
ISSN
0168-8227

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Type 2 (non-insulin-dependent) diabetes is associated with the deposition of islet amyloid. The major formative peptide, islet amyloid polypeptide, has recently been characterised and an abnormality of the structure or expression of this gene is a possible candidate for the inherited component of Ty

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Islet amyloid may have a pathological role in the development of Type 2 (non-insulin-dependent) diabetes mellitus. The prevalence of islet amyloid has been investigated on post-mortem pancreatic tissue from both diabetic and non-diabetic Pima Indian subjects who had previously been assessed by oral