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The Ionic Currents Underlying Pacemaker Activity in Rabbit Sino-Atrial Node: Experimental Results and Computer Simulations

โœ Scribed by Brown, H. F.; Kimura, J.; Noble, D.; Noble, S. J.; Taupignon, A.

Book ID
120142028
Publisher
The Royal Society
Year
1984
Tongue
English
Weight
564 KB
Volume
222
Category
Article
ISSN
0080-4649

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Block of the cardiac pacemaker current (
Block of the cardiac pacemaker current (If) in the rabbit sino-atrial node and in canine Purkinje fibres by 9-amino-1,2,3,4-tetrahydroacridine
โœ D. DiFrancesco; F. Porciatti; D. Janigro; G. Maccaferri; M. Mangoni; T. Tritella ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer ๐ŸŒ English โš– 508 KB

We have investigated the action of 9-amino-1, 2, 3, 4-tetrahydroacridine (THA) on the pacemaker current If in rabbit sino-atrial node myocytes and in canine Purkinje fibers. THA at concentrations in the range 3-300 microM blocked If in a voltage-independent manner, as revealed by measurements on the