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The effects of manganese and barium on the cardiac pacemaker current, if, in rabbit sino-atrial node myocytes

โœ Scribed by D. DiFrancesco; F. Porciatti; I. S. Cohen

Publisher
Springer
Year
1991
Tongue
English
Weight
406 KB
Volume
47
Category
Article
ISSN
1420-682X

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Block of the cardiac pacemaker current (
Block of the cardiac pacemaker current (If) in the rabbit sino-atrial node and in canine Purkinje fibres by 9-amino-1,2,3,4-tetrahydroacridine
โœ D. DiFrancesco; F. Porciatti; D. Janigro; G. Maccaferri; M. Mangoni; T. Tritella ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer ๐ŸŒ English โš– 508 KB

We have investigated the action of 9-amino-1, 2, 3, 4-tetrahydroacridine (THA) on the pacemaker current If in rabbit sino-atrial node myocytes and in canine Purkinje fibers. THA at concentrations in the range 3-300 microM blocked If in a voltage-independent manner, as revealed by measurements on the