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Some properties of the UL-FS 49 block of the hyperpolarization-activated current (if) in sino-atrial node myocytes

โœ Scribed by Dario DiFrancesco


Publisher
Springer
Year
1994
Tongue
English
Weight
763 KB
Volume
427
Category
Article
ISSN
0031-6768

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Block of the cardiac pacemaker current (
โœ D. DiFrancesco; F. Porciatti; D. Janigro; G. Maccaferri; M. Mangoni; T. Tritella ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer ๐ŸŒ English โš– 508 KB

We have investigated the action of 9-amino-1, 2, 3, 4-tetrahydroacridine (THA) on the pacemaker current If in rabbit sino-atrial node myocytes and in canine Purkinje fibers. THA at concentrations in the range 3-300 microM blocked If in a voltage-independent manner, as revealed by measurements on the