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The Involvement of Poly(ADP-ribose) Polymerase in the Degradation of NAD Caused by γ-Radiation and N-Methyl-N-Nitrosourea

✍ Scribed by Christopher J. SKIDMORE; Margaret I. DAVIES; Patricia M. GOODWIN; Haraldur HALLDORSSON; Pamela J. LEWIS; Sydney SHALL; Abed-Ali ZIA'EE

Book ID: 115117153
Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 663 KB
Volume: 101
Category: Article
ISSN: 1432-1327
DOI: 10.1111/j.1432-1033.1979.tb04225.x

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## Abstract Continuously generated hydrogen peroxide (H~2~O~2~) inhibits typical apoptosis and instead initiates a caspase‐independent, apoptosis‐inducing factor (AIF)‐mediated pyknotic cell death. This may be related to H~2~O~2~‐mediated DNA damage and subsequent ATP depletion, although the exact