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The Enhancement of Cytotoxicity of N-Methyl-N-nitrosourea and of y-Radiation by Inhibitors of Poly(ADP-ribose) Polymerase

✍ Scribed by Nsirim NDUKA; Christopher J. SKIDMORE; Sydney SHALL


Book ID
115118741
Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
516 KB
Volume
105
Category
Article
ISSN
1432-1327

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Effect of a poly(ADP-ribose) polymerase
✍ LuΓ­sa CristΓ³vΓ£o; JosΓ© Rueff πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 695 KB

The activity of poly(ADP-ribose) polymerase (PARP) is activated upon recognition of DNA strand breaks by its DNA-binding domain and the stimulation of this nuclear enzyme seems to be an early response of cells exposed to a variety of different DNA-damaging agents. In the present work we evaluate the