The involvement of p38 MAPK in transforming growth factor β1-induced apoptosis in murine hepatocytes
✍ Scribed by LIAO, Jin Hui; CHEN, Jun Song; CHAI, Min Qiang; ZHAO, Sheng; SONG, Jian Guo
- Book ID
- 110020437
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 307 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0007-0610
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## Abstract Transforming growth factor‐β1 (TGFβ1) is a multifunctional cytokine that is over expressed during liver hepatocytes injury and regeneration. SV40‐transformed CWSV‐1 rat hepatocytes that are p53‐defective undergo apoptosis in response to choline deficiency (CD) or TGFβ1, which mediates C
## BACKGROUND. Apoptosis is induced by various anticancer agents or radiation through the tumor suppressor gene p53-dependent pathway and is also induced by other factors, including transforming growth factor-PI (TGF-0,). In this study, the authors investigated whether TGF-0, would induce apoptosi
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