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The interaction of superoxide with nitric oxide destabilizes hypoxia-inducible factor-1α

✍ Scribed by B. Herr; J. Zhou; S. Dröse; B. Brüne

Publisher
Springer
Year
2007
Tongue
English
Weight
979 KB
Volume
64
Category
Article
ISSN
1420-682X

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## Abstract Dendritic cells (DC) are the most potent antigen‐presenting cells and during their life cycle they are exposed to different oxygen tensions. Similarly to inflamed and tumor tissues, lymphoid organs are characterized by a hypoxic microenvironment; thus, the modality by which hypoxia may