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The interaction of basic proteins from normal and multiple sclerosis myelin with phosphatidylglycerol vesicles

โœ Scribed by G.W. Brady; D.B. Fein; D.D. Wood; M.A. Moscarello

Book ID
115912461
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
187 KB
Volume
125
Category
Article
ISSN
0014-5793

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Myelin basic protein (MBP) occurs as a number of charge isomers due to phosphorylation, deamidation, and deimination of arginine to citrulline. All of these modifications decrease the net positive charge of the protein and its ability to cause aggregation of negatively charged lipid vesicles. This i