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Size and Surface Charge Properties of Myelin Vesicles from Normal and Diseased (Multiple Sclerosis) Brain

✍ Scribed by M. A. Moscarello; L.-S. Chia; D. Leighton; D. Absolom


Book ID
111173136
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
697 KB
Volume
45
Category
Article
ISSN
0022-3042

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Myelin basic protein (MBP) occurs as a number of charge isomers due to phosphorylation, deamidation, and deimination of arginine to citrulline. All of these modifications decrease the net positive charge of the protein and its ability to cause aggregation of negatively charged lipid vesicles. This i