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The interaction between magnetization transfer and blood-oxygen-level-dependent effects

✍ Scribed by Jinyuan Zhou; Jean-Francois Payen; Peter C. M. van Zijl

Book ID
102953823
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
613 KB
Volume
53
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Low‐power off‐resonance spin‐echo magnetization transfer (MT) imaging experiments with a long repetition time (TR) were performed on rat brain for a range of arterial __P__CO~2~ levels. The measured magnetization transfer ratio decreased with increased arterial __P__CO~2~ levels. When performing blood‐oxygen‐level‐dependent (BOLD) functional magnetic resonance imaging (fMRI)‐type data analysis in which signal intensities were normalized to the normocapnic state, the CO~2~‐based BOLD effect was much stronger with than without saturation. This increased effect is a consequence of the fact that the MT effect reduces the signal intensity in tissue more than in blood, thereby amplifying the contribution of the intravascular BOLD signal change to the overall BOLD effect. The results offer a potential approach to measure absolute cerebral blood volume in vivo and to amplify the BOLD effects for fMRI studies. Magn Reson Med 53:356–366, 2005. © 2005 Wiley‐Liss, Inc.

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