✦ LIBER ✦

The ins and outs of virulence gene expression: Mg2+ as a regulatory signal

✍ Scribed by Eduardo A. Groisman

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 260 KB
Volume: 20
Category: Article
ISSN: 0265-9247
DOI: 10.1002/(sici)1521-1878(199801)20:1<96::aid-bies13>3.0.co;2-3

No coin nor oath required. For personal study only.

✦ Synopsis

The facultative intracellular pathogen Salmonella enterica serovar Typhimurium faces multiple environments during infection, including different cell types as well as extracellular fluids. We propose that Salmonella ascertains its cellular location by assessing the Mg 2ϩ concentration of its milieu. A signal transduction system, PhoP/PhoQ, signals Salmonella its presence in a intracellular (low Mg 2ϩ ) or extracellular (high Mg 2ϩ ) environment, thereby promoting transcription of genes required for survival within or entry into host cells. The PhoP/PhoQ system is high in a regulatory hierarchy that controls other signal transduction systems that respond to different host cues, enabling the microorganism to determine its precise tissue and cellular location.

📜 SIMILAR VOLUMES

Calcium as a versatile second messenger

Calcium as a versatile second messenger in the control of gene expression

✍ Hardingham, Giles E.; Bading, Hilmar 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 77 KB 👁 1 views

The elevation of intracellular calcium is a major effector of stimulus-induced physiological change in a variety of cell types. Such change is invariably complex and frequently involves the activation of gene expression. Calcium signals are often able to activate different subsets of genes within th

Neurons and a Subset of Interstitial Cel

Neurons and a Subset of Interstitial Cells of Cajal in the Enteric Nervous System Highly Express Stam2 Gene

✍ Katarina Kapuralin; Chris Van Ginneken; Marija Curlin; Jean-Pierre Timmermans; S 📂 Article 📅 2011 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 341 KB 👁 1 views

Expression of Meis2, a Knotted-related m

Expression of Meis2, a Knotted-related murine homeobox gene, indicates a role in the differentiation of the forebrain and the somitic mesoderm

✍ Francesco Cecconi; Gabriele Proetzel; Gonzalo Alvarez-Bolado; Desmond Jay; Peter 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 247 KB 👁 2 views

Knotted (Kn) genes are expressed within restricted domains of the plant meristems and play a key role in the control of plant morphogenesis. We have isolated the Knrelated gene Meis2 in mouse, which labels the lateral somitic compartment and its derivatives during early mouse embryogenesis and later

Differential effects of the immunosuppre

Differential effects of the immunosuppressant FK-506 on human α2(I) collagen gene expression and transforming growth factor β signaling in normal and scleroderma fibroblasts

✍ Yoshihide Asano; Hironobu Ihn; Kenichi Yamane; Masatoshi Jinnin; Yoshihiro Mimur 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 480 KB 👁 1 views

Expression of Recombinant Human Tropoela

Expression of Recombinant Human Tropoelastin in Saccharomyces cerevisiae Containing a Synthetic Gene with a High Codon Adaptation Index Coupled to the SUC2 Invertase Signal Sequence

✍ P. Toonkool; A.S. Weiss 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 106 KB 👁 2 views

The changing faces of HP1: From heteroch

The changing faces of HP1: From heterochromatin formation and gene silencing to euchromatic gene expression : HP1 acts as a positive regulator of transcription

✍ So Hee Kwon; Jerry L. Workman 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 370 KB

## Abstract Heterochromatin protein 1 (HP1) is a positive regulator of active transcription in euchromatin. HP1 was first identified in __Drosophila melanogaster__ as a major component of heterochromatin. Most eukaryotes have at least three isoforms of HP1, which are conserved in overall structure