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Expression of Meis2, a Knotted-related murine homeobox gene, indicates a role in the differentiation of the forebrain and the somitic mesoderm

✍ Scribed by Francesco Cecconi; Gabriele Proetzel; Gonzalo Alvarez-Bolado; Desmond Jay; Peter Gruss

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 247 KB
Volume: 210
Category: Article
ISSN: 1058-8388
DOI: 10.1002/(sici)1097-0177(199710)210:2<184::aid-aja10>3.0.co;2-e

No coin nor oath required. For personal study only.

✦ Synopsis

Knotted (Kn) genes are expressed within restricted domains of the plant meristems and play a key role in the control of plant morphogenesis. We have isolated the Knrelated gene Meis2 in mouse, which labels the lateral somitic compartment and its derivatives during early mouse embryogenesis and later becomes a marker for the dorso-ectodermal region overlying cells of the paraxial mesoderm. Meis2 is also highly expressed in specific areas of the developing central nervous system from embryonic day 9 (e9) onward. In later developmental stages, a strong expression is detectable in differentiating nuclei and regions of the forebrain, midbrain, hindbrain, and spinal cord. This temporal and spatial expression pattern suggests that Meis2 may play an important role in the cascade of induction leading to somitic differentiation as well as in brain regionalization and histogenesis.

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