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The inhibition of the generation of thrombin and the antithrombotic effect of a pentasaccharide with sole anti-factor Xa activity

✍ Scribed by J.M. Walenga; L. Bara; M. Petitou; M. Samama; J. Fareed; J. Choay


Book ID
119037256
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
826 KB
Volume
51
Category
Article
ISSN
0049-3848

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Synthesis of an N-Acetylated Heparin Pen
✍ Hans Peter Wessel; Ludvik Labler; Thomas B. Tschopp πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 German βš– 714 KB

The synthesis of tri-N-acetylated heparin pentasaccharide 2 is described. It was assembled from five suitably blocked monosaccharide units (S7). Glucuronic-acid building block 4 was prepared from glucose by direct Jones oxidation of the 6-0-trityl derivative 18. The resulting acid 16 was esterified