The ING family tumor suppressors: from structure to function
✍ Scribed by Almass-Houd Aguissa-Touré; Ronald P. C. Wong; Gang Li
- Book ID
- 105759349
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 252 KB
- Volume
- 68
- Category
- Article
- ISSN
- 1420-682X
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## Abstract The Inhibitor of Growth 1 (ING1) gene has been identified and characterized as a Type‐II tumor suppressor gene (TSG). Subsequently, 4 additional members of the family were identified by homology search. ING proteins contain a nuclear localization sequence (NLS) and a plant homeo domain
## Abstract The INK4b‐ARF‐INK4a locus encodes two members of the INK4 family of cyclin‐dependent kinase inhibitors, p15^INK4b^ and p16^INK4a^, and a completely unrelated protein called ARF. ARF is a nucleolar protein with unusual structure that exhibits tumor suppressive functions. There is growing