The association between α-cyclodextrin and three monoalcohols (1-pentanol, 1-hexanol, and 1-heptanol) in (glycerol + water) was studied by titration microcalorimetry at T = (288. 15, 298.15, and 308.15) K. The apparent thermodynamic parameters for the binding reactions, the equilibrium constant K (o
The Influence of Variations of Ligand Protonation and Tautomerism on Protein—Ligand Recognition and Binding Energy Landscape.
✍ Scribed by Nikolay P. Todorov; Philippe H. Monthoux; Ian L. Alberts
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 8 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Affinity chromatography provides a powerful tool for isolation of carbohydrate-binding proteins. However, the choice of the ligand and spacer has an important impact on effectiveness. The influence of several different ligands on qualitative and quantitative aspects of the purification of two beta-g
The thermodynamics of molecular recognition is investigated by a statistical energy landscape approach, where the temperature profile of the ligand᎐protein binding process is determined using the weighted histogram analysis method. The analysis reveals differences in the binding energy landscapes of