✦ LIBER ✦

The influence of Unithiol and Spironolactone on the biliary excretion of203Hg in rat

✍ Scribed by M. Cikrt

Publisher: Springer-Verlag
Year: 1978
Tongue: English
Weight: 254 KB
Volume: 39
Category: Article
ISSN: 0340-5761
DOI: 10.1007/bf00368230

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✦ Synopsis

Rats with cannulated bile ducts were intravenously given 203HgCl2 in the dose of 120 microgram of Hg2+ per rat. Intramuscular administration of Unithiol (sodium 2,3-dimercaptopropanosulphonate) 4 and 7 h after 203Hg injection markedly increased both biliary and urinary excretion of 203Hg. In rats with Spironolactone (17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid, gamma-lactone, acetate) pretreatment the effect of Unithiol on the biliary excretion of 203Hg was enhanced. Urinary excretion of mercury was lowest in comparison with Unithiol treated group.

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